• Agarwal, Rajesh, Ph.D.
• Anchordoquy, Thomas J., Ph.D.
• Anderson, Peter, Pharm.D.
• Aquilante, Christina, Pharm.D.
• Bain, David L., Ph.D.
• Carpenter, John, Ph.D.
• Franklin, Christopher, Ph.D.
• Hail, Jr., Numsen, Ph.D.
• Irons, Richard D., Ph.D.
• Jones Braun, LaToya, Ph.D.
• Ju, Cynthia, Ph.D.
• Kiser, Jennifer, Pharm.D.
• Kompella Uday B., PhD
• Malkinson, Alvin M., Ph.D.
• Mallela, Krishna M. G., Ph.D.
• Maluf, N. Karl, Ph.D.
• Patel, Manisha, Ph.D.
• Petersen, Dennis R., Ph.D.
• Radcliffe, Richard, Ph.D.
• Ross, David, Ph.D.
• Ruth, James. A., Ph.D.
• Scheinman, Robert I., Ph.D.
• Thompson, John A., Ph.D.
• Vasiliou, Vasilis, Ph.D.

Richard Radcliffe, Ph.D.

Assistant Professor of Pharmacology, Department of Pharmaceutical Sciences

Mailing address:
4200 E. 9th Ave, C238
Denver, CO 80262

Telephone:
Voice:     303-315-1597
Lab:        303-315-6264
Fax:        303-315-6281
E-Mail:  Richard.Radcliffe@uchsc.edu

Affiliation:
Faculty Fellow, Institute for Behavioral Genetics

Training and Education:
B.S., Virginia Tech. Blacksburg, Virginia
Ph D., University of Colorado Denver, Denver, Colorado (Pharmaceutical Sciences).

Research Interests:
The basic goal of the lab is to map out neuronal pathways that influence behavior related to drug and alcohol abuse with an emphasis on the role of genetics. We use a wide variety of methods including quantitative trait loci (QTL) mapping, gene expression microarray analysis, various neurochemical assays, and behavioral testing. The work is conducted primarily in genetically defined strains of mice. A major focus of the lab is in defining the role of CNS gene expression in genetic differences in alcohol tolerance, and how that contributes to pathological alcohol-seeking behavior.

Teaching:
Professional Program: Physiology, Pharmacology
Graduate Program: Neurotoxicology, Drug Metabolism, Pharmacogenetics

Representative Publications:
Radcliffe, R. A., Floyd, K. L., Drahnak, J. A., and Deitrich, R. A. Genetic dissociation between ethanol sensitivity and rapid tolerance in mouse and rat strains selectively bred for differential ethanol sensitivity. Alcohol Clin Exp Res 29:1580-1589, 2005.
Radcliffe, R. A., Lee, M. J., and Williams, R. W. Prediction of cis-QTLs in a pair of inbred mouse strains with the use of expression and haplotype data from public databases. Mamm Genome 17:629-642, 2006
Smith, A. M., Bowers, B. J., Radcliffe, R. A., and Wehner, J. M. Microarray analysis of the effects of a γ-protein kinase C null mutation on gene expression in striatum: a role for transthyretin in mutant phenotypes. Behav Genet In press, 2006.
Radcliffe, R. A., Floyd, K. L., and Lee, M. J. Rapid ethanol tolerance mediated by adaptations in acute tolerance in inbred mouse strains. Pharmacol Biochem Behav In press, 2006.

Curriculum Vitae
Recent Publications

Last updated: 6/16/08