Michael F. Wempe, Ph.D.
Department of Pharmaceutical Sciences
Associate Research Professor and Director,
Medicinal Chemistry Core Facility
Mailing address:
C238-P15, Research 2
12700 E. 19th Ave., Room 4003
Aurora, CO 80045
Telephone:
Voice: 303-724-8982
Fax: 303-724-7266
E-Mail: Michael.Wempe@UCDenver.edu
Training and Education:
B.A., Hanover College; Hanover IN (Liberal Arts, Chemistry major)
M.S. Miami University, Oxford, Ohio, (Organic Chemistry)
Ph.D. Miami University, Oxford, Ohio, (Organic Chemistry)
Post-Doctoral Fellow, University of Rochester Medical School, Rochester, NY (Pharmacology and Physiology and Environmental Sciences (Toxicity)
Research Interests:
My laboratory uses chemical synthesis (organic and bio-organic) to produce known and novel compounds which are subsequently screened (in vitro) for their biological activity. Drug oral bioavailability may be influenced by low solubility, intrinsic instability, low membrane permeability, high first pass metabolism, and/or active excretion across the small intestine back into the intestinal lumen via efflux pumps. Consequently, we are interested and conduct fundamental research in drug metabolism, pharmacokinetics, and toxicity. 'Research' activities include: i) Medicinal Chemistry - rational drug design and Structure-Activity Relationship (SAR) elucidation; ii) computational chemistry; iii) developing novel technology to improve drug oral bioavailability; and iv) identifying new bio-analytical methodology.
Recent research articles:
M.F. Wempe, C. Wright, J.L. Little, J.W. Lightner, S.E. Large, G.B. Caflisch, C.M. Buchanan, P.J. Rice, V.J. Wacher, K.M. Ruble, K.J. Edgar “Inhibiting efflux with novel non-ionic surfactants: Rational design based on Vitamin E TPGS” Int. J. Pharm. 370(1-2): 93-102, 2009.
M.F. Wempe, J.W. Lightner, E.L. Zoeller, P.J. Rice “Investigating idebenone and idebenone linoleate: in vitro pig ear and mouse melanocyte studies” Journal of Cosmetic Dermatology 8(1): 63-73, 2009.
S. Klein, M.F. Wempe, T. Zoeller, N.L. Buchanan, J.L. Lambert, M.G. Ramsey, K.J. Edgar, C.M. Buchanan “Improving Glyburide Solubility and Dissolution by Complexation with Hydroxybutenyl-beta-Cyclodextrin” Journal of Pharmacy and Pharmacology 61: 23-30, 2009.
E. Morimoto, Y. Kanai, D.K. Kim, A. Chairoungdua, H.W Choi, M.F. Wempe, N. Anzai and H. Endou “Establishment and characterization of mammalian cell lines stably expressing human L-type amino acid transporters” J Pharmacol Sci 108: 505-516, 2008.4
E.L. Adams, P.J. Rice, B. Graves, H.E. Ensley, H. Yu, G.D. Brown, S. Gordon, M.A. Monteiro, E. Papp-Szabo, D.W. Lowman, T.D. Power, M.F. Wempe, and D.L. Williams "Differential high affinity interaction of Dectin-1 with natural or synthetic glucans is dependent upon primary structure and is influenced by polymer chain length and side chain branching." Journal of Pharmacology and Experimental Therapeutics 325: 115-123, 2008.
C.M. Buchanan, N.L. Buchanan, K.J. Edgar, J.L. Little, M.G. Ramsey, K.M. Ruble, V.J. Wacher, M.F Wempe"Pharmacokinetics of Saquinavir after Intravenous and oral dosing of saquinavir-Hydroxybutenyl-beta-cyclodextrin formulations"
Biomacromolecules 9: 305-313, 2008.
M.F. Wempe, V.J. Wacher, K.M. Ruble, M.G. Ramsey, K.J. Edgar, N.L. Buchanan, C.M. Buchanan "Pharmacokinetics of Raloxifene in Male Wistar-Hannover Rats: Influence of complexation with Hydroxybutenyl-beta-cyclodextrin" International Journal of Pharmaceutics 346(1-2):25-37, 2008.
C.M. Buchanan, N.L. Buchanan, K.J. Edgar, S. Klein, J.L. Little, K.M. Ruble, V.J. Wacher, M.F. Wempe "Pharmacokinetics of itraconazole after intravenous and oral dosing of itraconazole - cyclodextrin formulations" Journal of Pharmaceutical Sciences 96 (11) 3100-3116, 2007.
M.F. Wempe, C.M. Buchanan, N.L. Buchanan, K.J. Edgar, G.A. Hanley, M.G. Ramsey, J.S. Skotty and P.J. Rice "Pharmacokinetics of Letrozole in Male and Female Rats: Influence of complexation with Hydroxybutenyl-beta-cyclodextrin" Journal of Pharmacy and Pharmacology 59 (6) 795-802, 2007.
E-M. Collnot, C. Baldes, M.F. Wempe, R.Kappl, J.Hüttermann, J.A. Hyatt, K.J. Edgar, U.F. Schaefer, C-M Lehr "Mechanism of inhibition of P-glycoprotein mediated efflux by Vitamin E TPGS: Influence on ATPase activity and membrane fluidity" Molecular Pharmaceutics (4) 3 465-474, 2007.
C.M. Buchanan, N.L. Buchanan, K.J. Edgar, J.L. Little, M.O. Malcolm, K.M. Ruble, V.J. Wacher, M.F. Wempe "Pharmacokinetics of tamoxifen after intravenous and oral dosing of tamoxifen-hydroxybutenyl-beta-cyclodextrin formulations" Journal of Pharmaceutical Sciences 96 (3) 644-660, 2007.
C.M. Buchanan, N.L. Buchanan, K.J. Edgar, J. L. Lambert, J.D. Posey-Dowty, M.G. Ramsey, M.F. Wempe "Solubilization and dissolution of tamoxifen-hydroxybutenyl cyclodextrin complexes" Journal of Pharmaceutical Sciences 95 (10) 2246-2255, 2006.
J.L. Little, M.F. Wempe, and C.M. Buchanan" Liquid chromatography-tandem mass spectrometry method development: examining lipid matrix ionization effects in protein precipitated plasma" Journal of Chromatography B 833 (2), 219-230, 2006.
E-M Collnot, C. Baldes, M.F. Wempe, J.Hyatt, L. Navarro, K.J. Edgar, U.F. Schaefer, and C-M Lehr "Significance of vitamin E TPGS poly(ethylene glycol) chain length on apical efflux transporters in Caco-2 cell monolayers" Journal of Controlled Release 111 (1-2) 35-40, 2006.
Last updated: 8/04/09