Cyp2e1 and Cyp2e1/Cyp1a2-deficient mouse lines

Cyp2e1 and Cyp2e1/Cyp1a2 knockout mouse lines have been developed in Frank J. Gonzalez's laboratory. This page was created by Vasilis Vasiliou (66k photo). Last modified November 16, 1998.

Cyp2e1-null mice

• Lee SS, Buters JT, Pineau T, Fernandez-Salguero P, Gonzalez FJ. Role of CYP2E1 in the hepatotoxicity of acetaminophen. J Biol Chem 271:12063-12067, 1996.
• Valentine JL, Lee SS, Seaton MJ, Asgharian B, Farris G, Corton JC, Gonzalez FJ,Medinsky MA, Reduction of benzene metabolism and toxicity in mice that lack CYP2E1 expression. Toxicol Appl Pharmacol 141:205-213, 1996.

Cyp2e1/Cyp1a2 double knockout mouse line

• Zaher H, Buters JTM, Ward JM, Bruno MK, Lucas AM, Stern ST, Cohen SD, Gonzalez FJ. Protection against acetaminophen toxicity in CYP1A2 and CYP2E1double-null mice.Toxicol Appl Pharmacol 152:193-199, 1998.

Links

• University of Cincinnati Gene-Targeted Mouse Service

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E-mail questions or comments to: vasilis.vasiliou@ucdenver.edu