Pediatric Surgery Research
The Division of Pediatric Surgery focuses on research in several areas: post-traumatic inflammatory response in children, pediatric hepatobiliary diseases, minimally invasive surgery in children, and other clinical research. Members of the department have contributed numerous clinical studies in the following areas: appendectomy, gastroesophageal reflux, trauma, biliary atresia, kidney transplantation and others.
Dr. David Partrick continues his study of the inflammatory modulation in post-traumatic lung injury in children. An epidemiology study of post-traumatic multiple organ failure (MOF) in children is one of the projects included in the Trauma Research Center grant renewal submitted to the NIH.
James Wood, MD, is a current pediatric surgical research fellow working under Dr. Partrick’s supervision in the laboratory of Dr. Eugene Moore at the Denver Health Medical Center. Dr. Wood is continuing the studies previously initiated by past pediatric surgery research fellows.
In hepatobiliary diseases of children, the University of Colorado/Children’s Hospital is one of the lead centers in a multi-institutional NIH grant called the Biliary Atresia Research Consortium (BARC). Dr. Frederick Karrer sits on the surgery committee of the BARC, which will establish a database of clinical information, serum and tissue samples to investigate the etiology, treatment and outcome variables in biliary atresia. Locally, there are ongoing clinical hepatobiliary studies with the Pediatric CRC, the GI Division in the Department of Pediatrics, and the Division of Transplant Surgery.
Grants
In clinical research, there are numerous ongoing clinical studies, some of them funded by CRC protocols.
- Clinical Research Center Program Grant No. PR-00069: Sokol RJ, Narkewicz M, Karrer FM, Smith D, Butler-Simon N, Drescher A. Antioxidant Therapy in Biliary Atresia. The Children’s Hospital, Denver, CO. Protocol, 1999-