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Abernathy Review |
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August, 2008
Melanoma and Skin Cancer
Seminal Articles (i.e. practice changing or classic articles that all should know- read these and be prepared to discuss)
1. Gershenwald et al. Multi-institutional melanoma lymphatic mapping experience: the prognostic value of sentinel lymph node status in 612 stage I or II melanoma patients. J Clin Oncol. 1999 Mar;17(3):976-83.
2. Balch et al. Final version of the American Joint Committee on Cancer staging system for cutaneous melanoma. J Clin Oncol. 2001 Aug 15;19(16):3635-48.
3. Morton et al. Sentinel-node biopsy or nodal observation in melanoma. N Engl J Med. 2006 Sep 28;355(13):1307-17.
4. Thompson JF et al. Surgical management of primary cutaneous melanoma: excision margins and the role of sentinel lymph node examination. Surg Oncol Clin N Am. 2006 Apr;15(2):301-18.
General Knowledge Articles (i.e. scan these and keep them for general references – good reviews)
1. Lane JE and Kent DE. Surgical margins in the treatment of nonmelanoma skin cancer and mohs micrographic surgery. Curr Surg. 2005 Sep-Oct;62(5):518-26.
2. Essner R et al. Contemporary surgical treatment of advanced-stage melanoma. Arch Surg. 2004 Sep;139(9):961-6.
3. Morton et al. Technical details of intraoperative lymphatic mapping for early stage melanoma. Arch Surg. 1992 Apr;127(4):392-9. (Not included)
Discussion Points: (brief comments about topics not entirely covered above)
- Principles of non-melanoma skin cancer treatment
- Merkel cell carcinoma
- Historic evolution of melanoma surgery
- Surgical treatment impact on survival
- Molecular staging
- Limb perfusion/infusion for melanoma
- Desmoplastic melanoma
- Chemotherapy for melanoma (Dacarbazine = DTIC)
- Immunotherapy for melanoma (IL-2, IFN-alpha)
- Imiquimod (Aldara)