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November 2005
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Prostate, Lung, Colorectal & Ovarian screening clinic reaches milestone
For Manuela Ortiz, it was about keeping a family commitment. After 37 hours of travel, which included a car, two buses and an airplane, she arrived for her appointment at the last Prostate, Lung, Colorectal, and Ovarian (PLCO) screening clinic.

Manuela is one of more than 13,000 dedicated study participants at the University of Colorado Cancer Center (154,000 nationwide) who have made the largest screening trial in the nation possible. Although follow-up will go on until at least 2011, the PLCO reached a major milestone Oct. 4, completing the last of the clinical screenings.

Manuela Ortiz, a 67-year-old primary education professor, stands with Sally Tenorio, BSN, PLCO screener. Although Manuela lived in Colorado when she joined the Prostate, Lung, Colorectal & Ovarian (PLCO) study, she moved to a small town in Mexico two years ago to care for her ailing father. She traveled for 37 hours taking a car, two buses and an airplane to get to the last screening clinic of PLCO. Although PLCO offered some assistance with travel, Manuela’s family took up a collection to pay for additional travel expenses because they believe that her participation in the PLCO is “por nosotros y nuestros hijos, ” which translates to “for ourselves and our children.”

Recruitment for the trial began in 1993, when the National Cancer Institute spearheaded the national study to determine whether certain cancer screening tests reduce deaths from prostate, lung, colorectal and ovarian cancer. UCCC was one of only 10 centers in the nation selected to participate in the study.

Men and women between the ages of 55 and 74 joined. Half were selected by chance to receive specific screening tests, which included blood tests for prostate cancer or ovarian cancer, digital rectal exams for prostate cancer, chest x-rays for lung cancer, flexible sigmoidoscopy for colorectal cancer and a transvaginal ultrasound for ovarian cancer.

The other half received routine care by their personal health care providers. The screenings entailed annual visits to the PLCO clinic for six years and annual questionnaires and then follow-up questionnaires for seven more years to monitor participants’ health.

Manuela is part of a special recruitment that UCCC launched in 1998 with additional funding from the NCI to increase Hispanic participation. At that time, Colorado’s population was approximately 12.9 percent Hispanic, but the PLCO Hispanic enrollment was only 3.6 percent. To make the study more representative of Colorado’s population, the PLCO project staff developed the theme "Por Nosotros y Nuestros Hijos," which translates to "For Ourselves and Our Children” to increase Hispanic recruitment. The theme was used in all program materials, including advertisements, posters and pamphlets, and PLCO staff made personal visits to churches and other community organizations to encourage enrollment.

The efforts increased Hispanic enrollment from 295 to 1,278, which amounted to 10 percent of the study participants.

“ Regardless of ethnic background, nearly all of the PLCO participants take their role in this study very seriously,” said Sally Tenorio, BSN, clinical nurse and PLCO screener. “They understand that the study results will have effects for generations.”

Since the study population is so large and the time period is so extended, PLCO staff makes a concentrated effort to communicate regularly with participants to let them know how important every one of them is to the study.

“ We send quarterly newsletters to keep participants informed,” Ed Gamito, recruitment/retention coordinator with PLCO, said. “Sending birthday cards during the appropriate months and an annual holiday card with a pocket calendar is another way we let them know we are thinking about them. We will continue to do these things since we have several more years of follow-up.”

PLCO Facts:
Contract Awarded: 1992
Recruitment Began: 1993
Last Participant Enrolled: 2000
Last Screening: 2005
Follow-up ongoing until: at least 2011
Funding for UCCC study (including the National Lung Screening Trial, an offshoot of PLCO): $32,458,995
Number of participants in Colorado: 13,167

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